Biochemical effects of SIRT1 activators
نویسندگان
چکیده
منابع مشابه
Dietary activators of Sirt1.
Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histone deacetylase and its mammalian ortholog Sirt1. This association led to the search for potential ...
متن کاملSIRT1 Activators: The Evidence STACks up
The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters.
متن کاملResveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases.
Studies show that the plant polyphenol resveratrol can extend the life span of yeast, worms, flies, and fish. It also mitigates the metabolic dysfunction of mice fed high-fat diets. Resveratrol appears to mediate these effects partly by activating SIRT1, a deacetylase enzyme that regulates the activity of several transcriptional factors and enzymes responsive to nutrient availability. However, ...
متن کاملPharmacophore Mapping and Virtual Screening for SIRT1 Activators
Division of Applied Life Science (BK21 Program), Environmental Biotechnology National Core Research Center(EB-NCRC), Plant Molecular Biology and Biotechnology Research Center (PMBBRC), Gyeongsang National University, Jinju 660-701, Korea. *E-mail: [email protected] †Bio Computing Major, Korean German Institute of Technology, Seoul 157-033, Korea ‡Division of Quality of Life, Center of Bioanalysis...
متن کاملAre SIRT1 activators another indirect method to increase AMPK for beneficial effects on aging and the metabolic syndrome?
Article history: Received 18 April 2017 Accepted 18 April 2017 Available online 20 April 2017 studies (Price et al., 2012). Like Sirt1, AMPK is a highly conserved protein that has evolved to sense cellular energy status. Activation of AMPK in response to alterations in adenine nucleotides leads to the inhibition of energy consuming and actuating energy producing processes. Activation of AMPK ho...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
سال: 2010
ISSN: 1570-9639
DOI: 10.1016/j.bbapap.2009.10.025